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Impact of the miR-200 Family on H3K27me3 Levels and Tumour Microenvironment Communication within Triple Negative Breast Cancer.

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Title: Impact of the miR-200 Family on H3K27me3 Levels and Tumour Microenvironment Communication within Triple Negative Breast Cancer.
Author: Conquer-van Heumenn, Garret
Department: Department of Biomedical Sciences
Program: Biomedical Sciences
Advisor: Moorehead, Roger
Abstract: Triple Negative Breast Cancer has the worst prognosis out of the main breast cancer subtypes, and currently has no approved specific treatments. The miR-200 family has previously been characterized as inhibiting the initiation, progression, and metastasis of Triple Negative Breast Cancer. Previous work in our lab demonstrated a capacity to induce dormancy, and mediate changes to the epigenetic marker H3K27me3. This study used both TNBC cell lines and tumours which overexpressed the miR-200 family to investigate both immune-mediated and angiogenic-mediated mechanisms of tumour dormancy, along with the relationship between the miR-200 family and H3K27me3. Results indicated a significant positive relationship between the miR-200 family expression and H3K27me3 levels, implying that epigenetic modifications are a potential pathway for the exertion of the impacts brought on by miR-200 overexpression. Additionally, analysis of mechanisms of dormancy implicated both immune-mediated, and angiogenic-mediated dormancy as potential pathways for the miR-200 mediated dormancy effect demonstrated in vivo.
URI: https://hdl.handle.net/10214/25916
Date: 2021-06
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Related Publications: Simpson K, Conquer-van Heumen G, Watson KL, Roth M, Martin CJ, Moorehead RA. Re-expression of miR-200s in claudin-low mammary tumor cells alters cell shape and reduces proliferation and invasion potentially through modulating other miRNAs and SUZ12 regulated genes. Cancer Cell Int. 2021 Feb 4;21(1):89. doi: 10.1186/s12935-021-01784-4.


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