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Experimental and Computational Analyses of a Microfluidic Chip Fabricated Through Computer Numerical Control Micromilling of Stressed Polystyrene Sheets

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Title: Experimental and Computational Analyses of a Microfluidic Chip Fabricated Through Computer Numerical Control Micromilling of Stressed Polystyrene Sheets
Author: Leclerc, Camille
Department: School of Engineering
Program: Engineering
Advisor: Collier, Christopher
Abstract: The presented work describes a rapid microfluidic chip fabrication method utilizing the shrinking properties of stressed polystyrene sheets alongside the robust milling automation capabilities of a computerized numerical controller. The work described a rudimentary method to fabricate functional microfluidic chips within an hour and without the need of expensive laboratory equipment or a cleanroom environment. The corresponding research of this thesis determined the quantification of the geometrical shrinking properties of stressed polystyrene sheets based on geometrical features engraved onto the polymer substrate. An analysis of variance was performed, which provided empirical evidence that the shrinking properties of stressed polystyrene sheet differs based on the features engraved onto the polymer substrate. An image processing algorithm was developed and used to confirm the appropriate functionality of the fabricated microfluidic chips. The completed work highlights potential solutions towards overcoming the manufacturing challenges of microfluidic chips for widespread commercialization.
URI: https://hdl.handle.net/10214/25911
Date: 2021-06
Rights: Attribution-NonCommercial 4.0 International
Terms of Use: All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
Related Publications: Leclerc, C.A., Williams, S., Powe, C. et al. Rapid design and prototyping of microfluidic chips via computer numerical control micromilling and anisotropic shrinking of stressed polystyrene sheets. Microfluid Nanofluid 25, 12 (2021). https://doi.org/10.1007/s10404-020-02414-7


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Attribution-NonCommercial 4.0 International Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International