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An examination of the suitability of the TG epsilon 26 mouse as a model for pregnancy-induced hypertension

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Title: An examination of the suitability of the TG epsilon 26 mouse as a model for pregnancy-induced hypertension
Author: Luross, Jeffrey Arvid Lewis
Department: Department of Biomedical Sciences
Advisor: Croy, B. Anne
Abstract: Large granulated lymphocytes are transient at the maternal-fetal interface of rodents and humans. These are tissue-specific natural killer (NK)-cells of unknown function. Their abundance in the pregnant uterus and association with maternal blood vessels during every pregnancy in multiparous animals suggest an involvement in placental development. Histological observation of implantation sites from the uterine NK-cell deficient mouse, tg$\epsilon$26, revealed progressive uterine vascular histopathology coinciding with fetal loss. This parallels pre-eclampsia, a disease of unknown aetiology affecting human pregnancy that lacks a spontaneous animal model. The tg$\epsilon$26 mouse was evaluated as a pre-eclampsia model by measuring blood pressure and proteinuria during pregnancy, diagnostic criteria for pre-eclampsia. There was no difference in blood pressure or urinary protein concentration between pregnant and non-pregnant animals. Preliminary studies of renal ultrastructure in tg$\epsilon$26 mice indicated glomerular pathology. Further studies, required to complete characterisation of tg$\epsilon$26 mice as a spontaneous model for pre-eclampsia, are discussed.
URI: https://hdl.handle.net/10214/24067
Date: 1997
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