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Understanding the Impact of Muscle and Bony Injury in the Lumbar Spine - How Multifidus Muscle and Facet Joint Damage Impact Muscle Architecture and Joint Degeneration in the Rat

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dc.contributor.advisor Brown, Stephen
dc.contributor.author Klahsen, Olena
dc.date.accessioned 2021-01-04T14:13:40Z
dc.date.copyright 2020-12
dc.date.created 2020-12-03
dc.date.issued 2020-06
dc.identifier.uri https://hdl.handle.net/10214/23686
dc.description.abstract Rodent models that experience a mechanical injury to the facet joint have had contradicting results regarding the degree of osteoarthritis that the injured joint experiences. This thesis sought to answer if this disagreement was caused by surgical injury to the paraspinal multifidus muscle. It was expected that muscle and joint injury would drive changes in the muscle architecture, collagen content, facet joint transverse plane angle and characteristics of osteoarthritis. No consistent changes in any muscle measures were seen outside of the injured multifidus muscle, which had a decrease in mass and fascicle length while the collagen content increased. No changes in the facet joint angles or osteoarthritis statuses were seen. It is suspected that the degree of fibrosis for the injured muscle may have inhibited osteoarthritis processes. Future work should explore the role of paraspinal muscles in facet joint osteoarthritis using nonsurgical models. en_US
dc.description.sponsorship Ontario Government via the Ontario Graduate Scholarship, The National Science and Engineering Research Committee en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.rights Attribution-NonCommercial-ShareAlike 4.0 International *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/ *
dc.subject Spine en_US
dc.subject Surgical Injury en_US
dc.subject Facet Joint en_US
dc.subject Zygapophyseal Joint en_US
dc.subject Rodent Model en_US
dc.subject Osteoarthritis en_US
dc.subject Fibrosis en_US
dc.subject Collagen Content en_US
dc.subject Multifidus muscle en_US
dc.subject Muscle histology en_US
dc.subject Cartilage histology en_US
dc.title Understanding the Impact of Muscle and Bony Injury in the Lumbar Spine - How Multifidus Muscle and Facet Joint Damage Impact Muscle Architecture and Joint Degeneration in the Rat en_US
dc.type Thesis en_US
dc.degree.programme Human Health and Nutritional Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Human Health and Nutritional Sciences en_US
dc.description.embargo 2021-12-14
dcterms.relation Klahsen, O., Clark, A. and Brown, S.H.M. (2020) Multifidus and facet joint injury do not cause rapid joint degeneration. Canadian Bone and Joint Conference. en_US
dc.degree.grantor University of Guelph en_US


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