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The Cumulative Effects of Time-Varying Covariates in Survival Analysis

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Title: The Cumulative Effects of Time-Varying Covariates in Survival Analysis
Author: Lowe, Matthew
Department: Department of Mathematics and Statistics
Program: Mathematics and Statistics
Advisor: Horrocks, JulieDarlington, Gerarda
Abstract: Joint models for survival are modern statistical techniques for modelling the effect of time-varying covariates measured with error on the hazard of survival. Previous research has demonstrated that joint models have less bias compared to traditional Cox models with time-varying covariates. This thesis compares three association structures for joint models: the current value specification, the cumulative specification, and the weighted cumulative specification. The three methods were compared on two real data sets. A simulation study compared the three specifications when fit to data generated according to the current value specification. Results from the simulation show that the current value and weighted cumulative specifications provide similar estimates, with small bias and accurate standard deviation.
URI: https://hdl.handle.net/10214/23677
Date: 2020-11
Rights: Attribution 4.0 International


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