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Issues in comparative fungal genomics

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dc.contributor.author Hsiang, T.
dc.contributor.author Baillie, D.L.
dc.date.accessioned 2010-12-16T19:35:03Z
dc.date.available 2010-12-16T19:35:03Z
dc.date.issued 2006
dc.identifier.citation Hsiang, T.; Baillie, D.L. "Issues in comparative fungal genomics" Applied Mycology and Biotechnology 6 (2006): 99-122
dc.identifier.uri http://hdl.handle.net/10214/2365
dc.description.abstract Biologists face an overwhelming richness of nucleotide and protein sequence data. By the middle of 2005, there were almost 300 complete genomes that were publicly accessible. Most of these were archeal or bacterial since prokaryotic genomes are much smaller than eukaryotic genomes. Among eukaryotes, fungi, particularly yeasts, have some of the smallest genome sizes and hence represent the highest number of complete or almost complete genomes sequenced. By mid-2005, there were over 43 fungal genomes that were completely or almost completely sequenced and publicly accessible. What are the relationships among fungi and between fungi and other organisms? What type of genes and pathways are required for pathogenicity and other fungal lifestyles? Researchers are addressing these types of questions with data from high-throughput genomic sequencing. This review examines some recent uses of fungal genomic data in comparative genome analyses. Comparative genomics can facilitate research into the following areas: evolution, phylogenetics, targeted drugs, gene discovery, and gene function. Each of these is discussed as well as the availability and ownership of the genomic data, and the concepts of homology (homologs, orthologs, paralogs) and similarity.
dc.language.iso en en
dc.publisher Applied Mycology and Biotechnology en
dc.subject fungal genomics; homology en
dc.title Issues in comparative fungal genomics en
dc.type Article en
dc.contributor.affiliation School of Environmental Sciences
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