Main content

Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec

Show simple item record

dc.contributor.author Dewailley, Eric
dc.contributor.author Ayotte, Pierre
dc.date.accessioned 2010-04-29T18:58:53Z
dc.date.available 2010-04-29T18:58:53Z
dc.date.issued 2010-04-29T18:58:53Z
dc.identifier.uri http://hdl.handle.net/10214/2163
dc.description I7. Principal investigator: Pierre Ayotte en
dc.description.abstract Methylmercury (MeHg) exposure has been linked to an increased risk of cardiovascular diseases, in particular myocardial infarction. Paraoxonase 1 (PON1) is an enzyme located in the high density lipoprotein (HDL) fraction of blood lipids. It metabolizes toxic oxidized lipids associated with both low density liproprotein (LDL) and HDL. MeHg and various metals (Cd, Co, Cu, Fe, Mn, Ni, Zn) have been shown to inhibit PON1 activity in vitro but the relation between metal exposure and PON1 activity has not been studied in human populations. We hypothesize that mercury concentration in blood could be linked to decreased serum PON1 activity in populations highly exposed to methylmercury such as Aboriginal populations relying on fish for sustenance. PON1 activity will be determined in serum samples from participants to the Cree Health Survey who will be recruited in two Northern Quebec Cree communities to be visited in 2007. Associations between PON1 activity and metals will be tested, taking into consideration possible confounders. The influence of PON1 genotypes will be taken into consideration. In addition, we will examine possible relations between PON1 activity and the concentration of oxidized LDL, and the thickness of the carotid intima media. en
dc.description.sponsorship Metals in the Human Environment Strategic Network en
dc.language.iso en en
dc.relation.ispartofseries I;7
dc.subject Inuit communities en
dc.subject Cree communities en
dc.subject Cardiovascular diseases en
dc.subject Methylmercury en
dc.subject PON1 activity en
dc.title Relation Between Methylmercury Exposure and Serum Paraoxonase Activity in Cree and Inuit Communities of Northern Québec en
dc.type Other en


Files in this item

Files Size Format View
i7_ayotte.pdf 42.76Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record