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Investigation of Genomic Regions Affecting Ketosis in Dairy Cattle

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Title: Investigation of Genomic Regions Affecting Ketosis in Dairy Cattle
Author: Soares, Riani
Department: Department of Animal Biosciences
Program: Animal and Poultry Science
Advisor: Squires, JamesSchenkel, Flavio
Abstract: Ketosis is a severe metabolic disease caused by negative energy balance (NEB) that leads to decreased milk production. Thus, the main objectives were to investigate literature information on the genetic background of NEB, subclinical and clinical ketosis through a systematic review and meta-analysis and to identify genomic regions associated with subclinical and clinical ketosis in first and later lactations, and also for subclinical ketosis in two periods in early lactation (5 to 21 DIM and 22 to 45 DIM) by performing genome wide association studies (GWAS). The weighted single-step GBLUP (wssGBLUP) method was used for GWAS to identify genetic regions associated with the traits. The genes identified within the top-20 genomic windows were used for functional analyses. Biological understanding of this metabolic disease will help enhance accuracy of selection in the Canadian dairy cattle breeding programs and help with the development of biomarkers for early diagnosis and prevention of ketosis.
URI: https://hdl.handle.net/10214/21280
Date: 2020-09
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