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Investigating the effect of energy restriction for weight loss in obese cats on intake of essential nutrients and on serum metabolites

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Title: Investigating the effect of energy restriction for weight loss in obese cats on intake of essential nutrients and on serum metabolites
Author: Grant, Caitlin
Department: Department of Clinical Studies
Program: Clinical Studies
Advisor: Verbrugghe, Adronie
Abstract: Feline obesity is a widespread disease affecting a large proportion of pet cats. As a major health concern and as a risk factor for other comorbidities, obesity requires intervention and treatment. Treatment for obesity is calorie restriction, however, this can affect the intake of essential nutrients. Furthermore, it may induce changes in biochemical pathways of energy metabolism. Intake of essential amino acids and vitamins was investigated when obese cats were fed a veterinary therapeutic weight loss food for weight loss, and when cats were theoretically fed nine commercial cat diets including veterinary weight loss, over the counter (OTC) adult maintenance and OTC lite or low-calorie diets at 6 different energy restriction levels. Intake of each nutrient was compared to NRC recommendations. During actual weight loss, cats had intakes of arginine and choline that fell below NRC recommendations. For theoretical restriction, intake of all essential nutrients was greater with veterinary therapeutic diets compared to both OTC diets. For all diet types though, theoretical choline intake fell below NRC recommendations. Obesity-related effects on the serum metabolome in cats undergoing energy restriction for weight loss was investigated. Metabolites were analyzed using nuclear magnetic resonance (NMR) and Direct Flow Injection Mass Spectrometry (DI-MS) methods. With NMR analysis, glycine, l-alanine, l-histidine, l-glutamine, 2-hydroxybutyrate, isobutryric acid, citric acid, creatine, and methanol were greater in after energy restriction. Several differences in metabolite concentrations were identified by DI-MS. There was a greater concentration of long chain acylcarnitines and total amino acids in cats during energy restriction. More research is needed to elucidate energy metabolism and substrate utilization during energy restriction. Further exploration of obesity and energy restriction effects on intake of essential nutrients and the serum metabolome could lead to development of improved strategies to achieve weight loss in obese cats as well as prevention and treatment of health consequences related to obesity.
Date: 2020-09
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Embargoed Until: 2021-09-08

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