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Use of Intravenous Lidocaine to Treat Dexmedetomidine Induced Bradycardia in Sedated and Anesthetized Dogs

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Title: Use of Intravenous Lidocaine to Treat Dexmedetomidine Induced Bradycardia in Sedated and Anesthetized Dogs
Author: Tisotti, Tainor
Department: Department of Clinical Studies
Program: Clinical Studies
Advisor: Valverde, Alexander
Abstract: This thesis evaluated the use of intravenous lidocaine to treat the bradycardia associated with the administration of the sedative dexmedetomidine in canine anesthetic protocols. Research Beagle dogs were assigned to three different groups in a randomized crossover design that involved the administration of intravenous dexmedetomidine in different modalities of the anesthetic protocol. In two groups, dexmedetomidine was administered to dogs while awake and in the third group while anesthetized with isoflurane. After receiving dexmedetomidine, dogs were given intravenous lidocaine as a bolus 30 minutes later, followed by a second bolus and a constant rate infusion 20 minutes after the first bolus, in one of the awake groups and the anesthetized group. The other awake group received the lidocaine bolus and constant rate infusion 5 minutes after the dexmedetomidine. Intravenous lidocaine increased heart rate in awake and anesthetized dogs pre- treated with intravenous dexmedetomidine. Additional benefits from lidocaine administration included an increase in cardiac index and a decrease in systemic vascular resistance.
URI: https://hdl.handle.net/10214/21253
Date: 2020-09
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