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Structural and Immunochemical Investigation of Campylobacter jejuni Serotype HS:65

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Title: Structural and Immunochemical Investigation of Campylobacter jejuni Serotype HS:65
Author: Frame, Nolan
Department: Department of Chemistry
Program: Chemistry
Advisor: Monteiro, Mario
Abstract: Campylobacter jejuni is one of the leading global causes of human bacterial gastroenteritis. The development of C. jejuni glycoconjugate based vaccines from capsular polysaccharides has been investigated and has proven its efficacy. These cell surface polysaccharides may serve the bacteria as virulence factors and have been shown to have high variability between strains. The work enclosed in this research focuses on the characterization and development of a vaccine for serogroup HS:4, specifically the serotype HS:65. This work serves to assist in the development of a second-generation C. jejuni vaccine. Previously characterized strains within the serogroup HS:4 were shown to contain heptoses and 6-deoxy heptoses in unique configurations with non-stoichiometric additions of MeOPN. The proposed CPS structure of HS:65 is a disaccharide containing the unique heptose linked to glucose. As seen in Figure I, these monosaccharides were linked as: [→3)-6d-Hep/Hep-(1→4)-Glc-(1→] with no substitutions of the MeOPN unit.
Date: 2020-06
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Embargoed Until: 2021-07-30

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Attribution-NonCommercial-NoDerivatives 4.0 International Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International