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Extracellular Bactericidal Functions of Porcine Neutrophils

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dc.contributor.author Scapinello, Sarah Elizabeth
dc.date.accessioned 2010-01-12T20:38:36Z
dc.date.available 2010-01-12T20:38:36Z
dc.date.copyright 2009-12
dc.date.created 2009-12-17
dc.date.issued 2010-01-12T20:38:36Z
dc.identifier.uri http://hdl.handle.net/10214/2105
dc.description.abstract Neutrophils are one of the main effector cells of innate immunity and were shown to kill bacteria by phagocytosis more than 100 years ago. Neutrophils are also capable of antimicrobial activity by producing extracellular structures named neutrophil extracellular traps (NETs). This thesis is an investigation of porcine neutrophils and their ability to produce NETs, as well as the antimicrobial ability of secretions from activated porcine neutrophils in combating a variety of common porcine pathogens. Porcine neutrophils were found to produce NET-like structures, and secretions from activated neutrophils were found to possess variable bactericidal activity against common pathogens of swine. Antimicrobial proteins dependent on elastase activity were shown to be partially responsible for the bactericidal activities of activated neutrophils. Several antimicrobial proteins and peptides were identified via proteomic techniques. This work allows for better understanding of innate immunity in swine, and identification of potential targets for addressing porcine health. en_US
dc.description.sponsorship Ontario Ministry of Agriculture Food & Rural Affairs, Ontario Pork, Natural Sciences and Engineering Research Council of Canada en_US
dc.language.iso en en_US
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ *
dc.subject Neutrophil Extracellular Traps en_US
dc.subject Pigs en_US
dc.subject Host Defence Peptides en_US
dc.subject Cathelicidin en_US
dc.subject Bacterial Killing en_US
dc.subject Extracellular Killing en_US
dc.subject Innate Immunity en_US
dc.subject Neutrophil en_US
dc.title Extracellular Bactericidal Functions of Porcine Neutrophils en_US
dc.type Thesis en_US
dc.degree.programme Pathobiology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Pathobiology en_US
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