Factors Associated with Extended-Spectrum β-Lactamase Producing Enterobacteriaceae Colonization and/or Infections in Humans: A Protocol for a Scoping Review

Abstract

Background. Antimicrobial-resistant bacteria are a growing concern for Canadians, leaving them vulnerable to untreatable infections and increasing the risk associated with elective medical procedures. Extended-spectrum β-lactamase-producing Enterobacteriaceae are becoming more prevalent in Canada, and risks for human exposure and subsequent infection are being increasingly studied. Objective. The objective of this scoping review is to characterize factors associated with extended-spectrum β-lactamase-producing Enterobacteriaceae colonization and/or infections in humans that have been described in the literature to date. Design. Primary research, systematic reviews, and meta-analysis available in English will be collected from online databases with no date restrictions. Studies will be retained if they report quantified associations between factors and extended-spectrum β-lactamase -producing Enterobacteriaceae colonization and/or infections in humans who live in Canada or in a country with a very high human development index.