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Investigating single-nucleotide variants in swine associated with common infectious pathogens and diseases, with a focus on Streptococcus suis infection, using a genome-wide association study approach

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Title: Investigating single-nucleotide variants in swine associated with common infectious pathogens and diseases, with a focus on Streptococcus suis infection, using a genome-wide association study approach
Author: Wong, Jeremy
Department: Department of Pathobiology
Program: Pathobiology
Advisor: Lillie, BrandonFarzan, Abdolvahab
Abstract: Infectious diseases are major burdens for the swine industry. Host genetics is an important factor in the outcome of host-pathogen interactions. Single-nucleotide variants in pigs were associated with the presence of common pathogens and infectious diseases via genome-wide association studies. In the first study, 461 cases diagnosed with diseases or pathogens and 1003 controls were investigated; the second study analyzed 40 cases diagnosed with Streptococcus suis disease and 23 controls from twelve farms. Data were analyzed using the genome-wide efficient mixed model association algorithm (GEMMA). In study one, a variant in AGAP1 was significantly associated with Salmonella Typhimurium(p<5.0×10-7). Variants in ATP2B1, DPYD, PID1, AGAP1, SNTB1, ACVRL1, NIFK, and MALL were suggestively associated with various bacterial and viral pathogens, and swine diseases(p<1.0×10-5). In study two, variants in PLEKHM1, LRRC37A, and WNT3 were suggestively associated with S. suis disease(p<1.0×10-5). These results may help breeding programs improve the robustness of pigs.
URI: http://hdl.handle.net/10214/18037
Date: 2020-06
Rights: Attribution-ShareAlike 4.0 International
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Attribution-ShareAlike 4.0 International Except where otherwise noted, this item's license is described as Attribution-ShareAlike 4.0 International