Title:
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Investigating single-nucleotide variants in swine associated with common infectious pathogens and diseases, with a focus on Streptococcus suis infection, using a genome-wide association study approach |
Author:
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Wong, Jeremy
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Department:
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Department of Pathobiology |
Program:
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Pathobiology |
Advisor:
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Lillie, Brandon Farzan, Abdolvahab |
Abstract:
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Infectious diseases are major burdens for the swine industry. Host genetics is an important factor in the outcome of host-pathogen interactions. Single-nucleotide variants in pigs were associated with the presence of common pathogens and infectious diseases via genome-wide association studies. In the first study, 461 cases diagnosed with diseases or pathogens and 1003 controls were investigated; the second study analyzed 40 cases diagnosed with Streptococcus suis disease and 23 controls from twelve farms. Data were analyzed using the genome-wide efficient mixed model association algorithm (GEMMA). In study one, a variant in AGAP1 was significantly associated with Salmonella Typhimurium(p<5.0×10-7). Variants in ATP2B1, DPYD, PID1, AGAP1, SNTB1, ACVRL1, NIFK, and MALL were suggestively associated with various bacterial and viral pathogens, and swine diseases(p<1.0×10-5). In study two, variants in PLEKHM1, LRRC37A, and WNT3 were suggestively associated with S. suis disease(p<1.0×10-5). These results may help breeding programs improve the robustness of pigs. |
URI:
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http://hdl.handle.net/10214/18037
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Date:
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2020-06 |
Rights:
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Attribution-ShareAlike 4.0 International |
Terms of Use:
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