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Developing a Broader Understanding of the Effects of Fecal Microbiota Transplantation on the Health and Microbiome of Donors and Patients with Recurrent Clostridiodes difficile Infection

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Title: Developing a Broader Understanding of the Effects of Fecal Microbiota Transplantation on the Health and Microbiome of Donors and Patients with Recurrent Clostridiodes difficile Infection
Author: Harris, Cailin
Department: Department of Mathematics and Statistics
Program: Bioinformatics
Advisor: Kim, Peter
Abstract: This collection of papers investigates Clostridiodes difficile infection (CDI) and its treatment with fecal microbiota transplantation (FMT) from a more holistic perspective. Bacterial composition of FMT donors and patients with CDI at 4 timepoints (pre-FMT, 10 days, 5 weeks, and 13 weeks post-FMT) were analyzed from 16S rRNA sequence data. Trends in microbiome composition pre and post treatment with FMT were observed to establish which bacteria are responsible for curing patients of CDI and restoring quality of life. Bacterial composition was found to adjust over time after treatment to more closely resemble healthy donors. Donors were studied to identify if bacterial diversity remained stable between donors and were found to have no significant difference in Shannon diversity, indicating similarly diverse bacteria were supplied to each patient. By obtaining a more holistic view, we aim to understand the mechanisms of FMT better and produce precision care for patients suffering from CDI.
URI: http://hdl.handle.net/10214/18011
Date: 2020-05
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