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Antibody responses to porcine reproductive and respiratory syndrome virus, influenza A virus, and Mycoplasma hyopneumoniae and their association with single-nucleotide variants

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Title: Antibody responses to porcine reproductive and respiratory syndrome virus, influenza A virus, and Mycoplasma hyopneumoniae and their association with single-nucleotide variants
Author: Raaphorst, Elana
Department: Department of Pathobiology
Program: Pathobiology
Advisor: Lillie, BrandonFarzan, Vahab
Abstract: Swine respiratory diseases are a significant problem for pork producers. This study analyzed antibody responses to porcine reproductive and respiratory syndrome virus (PRRSV), influenza A virus (IAV), and Mycoplasma hyopneumoniae (M. hyopneumoniae), their association with variants in the porcine genome, and the effects of nursery diet complexity on antibody levels. Fourteen groups of pigs (n=618) from 8 farrowing sources were tested 4 times from weaning to the end of the grower-finisher stage. Blood samples were genotyped, and sera were analyzed for antibodies using commercial ELISAs. Data were analyzed using mixed-effects multi-level logistic regression methods. Pigs were more likely to test seropositive at weaning compared to end of nursery for all three pathogens (p<0.05). Variants in/near RAB38 and BRINP3 for PRRSV; PARP14, ADCY6, and TG for IAV; and ENSSSCG00000051043, DNASE1L3, and TEKT2 for M. hyopneumoniae seropositivity were approaching suggestive associations. These findings may help identify options for improved swine breeding programs.
URI: http://hdl.handle.net/10214/18007
Date: 2020-05
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Raaphorst_Elana_202005_MSc.pdf 1.125Mb PDF View/Open Entire thesis by Elana Raaphorst in fulfilment of a MSc degree in the Department of Pathobiology

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