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Reactive Neurogenesis in the Forebrain of the Leopard Gecko

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dc.contributor.advisor Vickaryous, Matthew
dc.contributor.author Austin, Laura
dc.date.accessioned 2020-04-22T21:09:02Z
dc.date.available 2020-04-22T21:09:02Z
dc.date.copyright 2020
dc.date.created 2020-04-02
dc.date.issued 2020-04-22
dc.identifier.uri http://hdl.handle.net/10214/17876
dc.description.abstract Neurogenesis is the ability to generate new neurons from resident stem/progenitor populations. Although best understood as a homeostatic process, several species of teleost fish and salamanders are also capable of replacing neurons lost due to injury – so called reactive neurogenesis. Here, I investigated reactive neurogenesis in the lizard Eublepharis macularius, the leopard gecko. To initiate reactive neurogenesis, I administered a single dose of the antimetabolite 3-acetylpyridine (3-AP). Four days following 3-AP administration, there is widespread evidence of cell death and microglia activation within the medical cortex, the homologue of the mammalian hippocampus. As evidenced by reduced expression of the neuronal marker NeuN, 3-AP appears to selectively target mature neurons. 30 days following 3AP administration, the medial cortex appears to be structurally restored with a pattern of NeuN expression that closely resembles the uninjured brain. Together, these data provide the first evidence that the leopard gecko is capable of reactive neurogenesis. en_US
dc.description.sponsorship NSERC, CFI en_US
dc.language.iso en en_US
dc.subject Neurogenesis en_US
dc.subject Regeneration en_US
dc.subject Leopard gecko en_US
dc.subject Medial cortex en_US
dc.subject Brain regeneration en_US
dc.subject Neurotoxic lesion en_US
dc.subject Reactive neurogenesis en_US
dc.title Reactive Neurogenesis in the Forebrain of the Leopard Gecko en_US
dc.type Thesis en_US
dc.degree.programme Biomedical Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Biomedical Sciences en_US
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