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The Ovine Inflammatory Response to Lipopolysaccharide and Association with the Stress Response Phenotype

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dc.contributor.advisor Karrow, Niel Naylor, Danielle 2020-04-13T20:13:47Z 2020-04-13T20:13:47Z 2020-03 2020-02-26 2020-04-13
dc.description.abstract Improving the stress resiliency of livestock is a strategy that can be used to mitigate the negative impacts of stressors that are anticipated to worsen due to climate change. The hypothalamic-pituitary-adrenal axis is the major neuroendocrine stress response system, and its activation demonstrates individual variation and heritability, giving rise to a novel health phenotype—the stress response phenotype—that could be considered in selection criteria for livestock breeding programs. The immune system is also activated during stress events and the interaction with the neuroendocrine system could dictate stress resiliency. Therefore, the purpose of this thesis was to assess a comprehensive panel of circulatory mediators as potential immune stress biomarkers during a systemic lipopolysaccharide challenge, and whether these biomarkers are differentially regulated in variable stress responding sheep. en_US
dc.description.sponsorship This research was financially supported by the University of Guelph's Food from Thought research program, funded by the Canada First Research Excellence Fund, the Ontario Ministry of Agriculture and Food, and by the MITACS Elevate program. en_US
dc.language.iso en en_US
dc.rights Attribution-ShareAlike 4.0 International *
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dc.subject sheep en_US
dc.subject stress en_US
dc.subject stress resiliency en_US
dc.subject biomarkers en_US
dc.subject inflammation en_US
dc.subject lipopolysaccharide en_US
dc.subject microRNA en_US
dc.subject cytokines en_US
dc.subject white blood cells en_US
dc.subject cortisol en_US
dc.subject stress response phenotype en_US
dc.subject immune response en_US
dc.subject stress response en_US
dc.title The Ovine Inflammatory Response to Lipopolysaccharide and Association with the Stress Response Phenotype en_US
dc.type Thesis en_US Animal and Poultry Science en_US Master of Science en_US Department of Animal Biosciences en_US
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Attribution-ShareAlike 4.0 International Except where otherwise noted, this item's license is described as Attribution-ShareAlike 4.0 International