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The Ovine Inflammatory Response to Lipopolysaccharide and Association with the Stress Response Phenotype

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Title: The Ovine Inflammatory Response to Lipopolysaccharide and Association with the Stress Response Phenotype
Author: Naylor, Danielle
Department: Department of Animal Biosciences
Program: Animal and Poultry Science
Advisor: Karrow, Niel
Abstract: Improving the stress resiliency of livestock is a strategy that can be used to mitigate the negative impacts of stressors that are anticipated to worsen due to climate change. The hypothalamic-pituitary-adrenal axis is the major neuroendocrine stress response system, and its activation demonstrates individual variation and heritability, giving rise to a novel health phenotype—the stress response phenotype—that could be considered in selection criteria for livestock breeding programs. The immune system is also activated during stress events and the interaction with the neuroendocrine system could dictate stress resiliency. Therefore, the purpose of this thesis was to assess a comprehensive panel of circulatory mediators as potential immune stress biomarkers during a systemic lipopolysaccharide challenge, and whether these biomarkers are differentially regulated in variable stress responding sheep.
URI: http://hdl.handle.net/10214/17849
Date: 2020-03
Rights: Attribution-ShareAlike 4.0 International
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Attribution-ShareAlike 4.0 International Except where otherwise noted, this item's license is described as Attribution-ShareAlike 4.0 International