Main content

The Effects of Bisphenol-A and its Analogs on Neuronal Oestrogen Sensitive Kinase Pathways.

Show full item record

Title: The Effects of Bisphenol-A and its Analogs on Neuronal Oestrogen Sensitive Kinase Pathways.
Author: Akshara, Akshara
Department: Department of Biomedical Sciences
Program: Biomedical Sciences
Advisor: MacLusky, Neil
Abstract: Bisphenol-A (BPA) is a major endocrine-disrupting chemical, which interferes with several cell signaling pathways. Although studies have suggested that BPA acts as a weak oestrogen agonist at the nuclear oestrogen receptor, ERα, in the brain BPA inhibits anti-oestrogenic effects. This project tested the hypothesis that BPA is a functional agonist/antagonist of the G-protein coupled oestrogen receptor (GPER), via activation of c-Jun-N-terminal kinase (JNK) in neurons. At the same time, I asked whether the widely-used BPA substitutes, Bisphenol-S (BPS) and Bisphenol-F (BPF) might exert effects similar to those of BPA, using the mHippoE-14 (immortalized fetal mouse neuronal) and SH-SY5Y (human female neuroblastoma) cell lines. BPA, BPS and BPF all significantly inhibited GPER – mediated activation of JNK phosphorylation, as well as ERK1/2 phosphorylation. These data suggest that BPA, BPS, and BPF may be the functional antagonists of GPER-mediated oestrogen signaling in the brain.
URI: http://hdl.handle.net/10214/17766
Date: 2020-01
Terms of Use: All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.


Files in this item

Files Size Format View
Akshara_Akshara_202001_Msc.pdfuntranslated 3.917Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record