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Novel chromosomal polymorphisms identified in North American Atlantic salmon (Salmo salar) using a high-density linkage map generated from a 50K SNP array

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Title: Novel chromosomal polymorphisms identified in North American Atlantic salmon (Salmo salar) using a high-density linkage map generated from a 50K SNP array
Author: Mac Leod-Bigley, Melissa
Department: Department of Integrative Biology
Program: Bioinformatics
Advisor: Boulding, Elizabeth
Abstract: Atlantic salmon (Salmo salar) contain a complex genome structure that may present polymorphic chromosomal rearrangements between different populations. For example, European and North American populations of S. salar have been shown to exhibit 29 and 27 chromosomes, respectively. Genetic linkage maps allow us to better study and understand these chromosomal rearrangements. My goal was to construct high-density SNP-based linkage maps for North American S. salar using the R package OneMap. Individual maps contained an average of 13,114 SNPs for each of nine full-sibling families, with lengths of female and male maps averaging 3,034.83 cM and 1659.11 cM, respectively, with an average female to male ratio of 1.83:1. My findings provide higher resolution mapping that allow for identification of the correct orientation of three chromosomal polymorphisms already observed in North American S. salar (Ssa01p/23, Ssa08/29, Ssa26/28) as well as evidence for three novel chromosomal polymorphisms (Ssa06, Ssa11, and Ssa16).
URI: http://hdl.handle.net/10214/17750
Date: 2019-12
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MacLeodBigley_Melissa_202001_MSc.pdfuntranslated 943.2Kb PDF View/Open Main Article (Thesis)
Supplementary File S2.1.zipuntranslated 515.5Kb Unknown View/Open Data - Linkage Maps (female)
Supplementary File S2.2.zipuntranslated 464.1Kb Unknown View/Open Data - Linkage Maps (male)

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