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A case-control study to investigate the serotypes and untypable Streptococcus suis strains recovered from nursery pigs on 12 farms in Ontario, Canada between 2017 and 2018

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Title: A case-control study to investigate the serotypes and untypable Streptococcus suis strains recovered from nursery pigs on 12 farms in Ontario, Canada between 2017 and 2018
Author: Denich, Leann
Department: Department of Population Medicine
Program: Population Medicine
Advisor: Poljak, ZvonimirFarzan, Vahab
Abstract: Streptococcus suis is an important bacterial pathogen in swine that naturally colonizes the nasal cavity and tonsil of many pigs. Outbreaks tend to be sporadic and are typically seen in piglets 4-8-weeks of age. It is still unclear why some pigs remain healthy, while others become systemically ill with infection. A case-control study was conducted to better understand the serotypes and untypable strains that are recovered from clinically ill and healthy pigs from Ontario nursery pigs. Firstly, we identified that the S. suis serotypes most commonly found in clinically ill pigs, from systemic sites included serotype (2,1/2), 9 and untypable isolates. There was also no association between serotypes found in upper respiratory sites of clinically ill and healthy pigs. Secondly, based on whole genome sequencing we determined that untypable isolates could be classified into 3 groups with respect to their similarity to existing serotypes which included ≥99% similar, between 50-98% similar or <50% similar to existing serotypes.
URI: http://hdl.handle.net/10214/17734
Date: 2020
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