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Regulation of the cortisol stress response during and after exposure to chronic and severe hypoxia in crucian carp (Carassius carassius) and goldfish (Carassius auratus)

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dc.contributor.advisor Bernier, Nicholas
dc.contributor.author Alcorn, Michael
dc.date.accessioned 2019-09-11T15:35:20Z
dc.date.available 2019-09-11T15:35:20Z
dc.date.copyright 2019-07
dc.date.created 2019-09-05
dc.date.issued 2019-09-11
dc.identifier.uri http://hdl.handle.net/10214/17427
dc.description.abstract To reduce energy utilization and survive extended periods without oxygen, hypoxia-tolerant animals must regulate the production of the catabolic stress hormone, cortisol. To quantify this response, crucian carp and goldfish were exposed to chronic hypoxic conditions and either sampled immediately or recovered in normoxia. While crucian carp reduced plasma cortisol levels in response to anoxia, severe hypoxia and early reoxygenation increased the circulating levels of cortisol in goldfish. In both species, the first 24 h of recovery were also characterized by a general reduction in head kidney steroidogenic enzyme expression. In contrast, recovery was associated with marked increases in the expression of genes involved in cortisol catabolism and in the mRNA levels of liver leptin, a known inhibitory cytokine of the stress response. These results suggest crucian carp and goldfish utilize several mechanisms to regulate the production of cortisol during and after severe hypoxia exposure. en_US
dc.language.iso en en_US
dc.rights Attribution-ShareAlike 4.0 International *
dc.rights.uri http://creativecommons.org/licenses/by-sa/4.0/ *
dc.subject Cortisol en_US
dc.subject Stress en_US
dc.subject Fish en_US
dc.subject Hypoxia en_US
dc.subject Leptin en_US
dc.title Regulation of the cortisol stress response during and after exposure to chronic and severe hypoxia in crucian carp (Carassius carassius) and goldfish (Carassius auratus) en_US
dc.type Thesis en_US
dc.degree.programme Integrative Biology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Integrative Biology en_US
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Attribution-ShareAlike 4.0 International Except where otherwise noted, this item's license is described as Attribution-ShareAlike 4.0 International