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Effects of oral gabapentin, tramadol and meloxicam on ocular parameters in healthy dogs

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dc.contributor.advisor Pinard, Chantale Shukla, Angelie 2019-09-09T13:33:12Z 2019-09-09T13:33:12Z 2019-08 2019-08-28 2019-09-09
dc.description.abstract EFFECTS OF ORAL GABAPENTIN, TRAMADOL AND MELOXICAM ON OCULAR PARAMETERS IN HEALTHY DOGS The objectives of this study were to determine the effects of oral gabapentin, tramadol and meloxicam on ocular parameters when given to healthy dogs for three days. Nine, healthy, intact male Beagles were utilized for a randomized, blinded, case-crossover study using a 6-sequence, 3-treatment, 3-period design, including a 7-day acclimation period, three, 3-day treatment periods followed by a 7-day washout period. Dogs received gabapentin (10mg/kg PO q8hr), tramadol (3mg/kg PO q8hr), and meloxicam (0.2mg/kg PO once, then 0.1mg/kg PO q24). Ocular parameters were evaluated several times per day. Comparing acclimation period measurements from days 1-5 and 6-7 confirmed that a 5-day acclimation period is required for intraocular pressure values to return to baseline in canine patients (p-value = 0.0021). When accounting for repeat measures within individuals, gabapentin and tramadol significantly affected only IOP (-0.45 and -0.35mmHg, respectively; p-value = 0.038). Although statistically significant, this reduction is not considered clinically significant. en_US
dc.description.sponsorship Ontario Veterinary College Pet Trust en_US
dc.language.iso en en_US
dc.subject Schirmer tear test en_US
dc.subject Intraocular pressure en_US
dc.subject Pupillary diameter en_US
dc.subject Tear break-up time en_US
dc.subject Corneal touch threshold en_US
dc.subject Gabapentin en_US
dc.subject Meloxicam en_US
dc.subject Tramadol en_US
dc.subject Dog en_US
dc.subject TonoVet en_US
dc.title Effects of oral gabapentin, tramadol and meloxicam on ocular parameters in healthy dogs en_US
dc.type Thesis en_US Clinical Studies en_US Master of Science en_US Department of Clinical Studies en_US
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