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Carbon Dioxide Pneumoperitoneum and Laparoscopic Ovariectomy in the Domestic Rabbit (Oryctolagus cuniculus)

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dc.contributor.advisor Singh, Ameet
dc.contributor.advisor Beaufrere, Hugues
dc.contributor.author Kabakchiev, Claudia
dc.date.accessioned 2019-09-04T20:16:14Z
dc.date.available 2019-09-04T20:16:14Z
dc.date.copyright 2019-04
dc.date.created 2019-06-18
dc.date.issued 2019-09-04
dc.identifier.uri http://hdl.handle.net/10214/17375
dc.description.abstract Laparoscopic surgeries are increasingly popular in exotic companion mammals, but information about their benefits or disadvantages is limited. The aims of this thesis are: 1) to assess the working space achieved with carbon dioxide pneumoperitoneum in rabbits; 2) to evaluate the cardiorespiratory effects of pneumoperitoneum; and 3) to compare intra-operative and post-operative outcomes between laparoscopic and open ovariectomy in rabbits. For the first two cross-over studies, six female New Zealand White rabbits were randomly assigned to sequences of intra-abdominal pressures (IAP). Computed tomography (CT) was used to measure working space after insufflation to 4, 8, and 12 mm Hg. From 4 to 8 mmHg, there was a 19% increase in working space, whereas from 8 to 12 mm Hg the increase was only 6.9%. The order of IAPs affected working space. To assess the effect of pneumoperitoneum on cardiorespiratory parameters, the following outcomes were measured at 0, 4, and 8 mm Hg: blood pressures (ABP); cardiac output, cardiac and stroke volume indices (CI, SVI); heart rate; end-tidal CO2 (ETCO2); blood gases (PaCO2, PaO2); peak inspiratory pressure (PIP); and peripheral oxygen saturation (SpO2). Heart rate, SpO2, and ABP were unaffected by IAP. For PaO2, an interaction effect was seen between IAP and pressure sequence. PaCO2 increased at 8 mm Hg, and ETCO2 and PIP were greater with each IAP. IAP decreased cardiac output and CI. Intra-operative and post-operative outcomes between laparoscopic (LapOVE) and open ovariectomy (OVE) were compared in female New Zealand White rabbits randomly allocated to surgical treatments (n=6 per group). Surgical and anaesthetic time were longer and incision length was shorter for LapOVE versus OVE. There were no significant differences in post-operative outcomes between the treatments, including ethograms evaluated by a blinded observer. Surgical complications associated with LapOVE included intestinal perforation, subcutaneous emphysema, and seroma formation. Incisional dehiscence occurred in both groups. In summary, pneumoperitoneal pressures should be limited to 8 mm Hg in rabbits. When performing ovariectomy in rabbits, laparoscopy may not provide as marked of an advantage over open approaches as in other mammals. However, further evaluation of laparoscopic techniques is warranted for this species. en_US
dc.description.sponsorship OVC Pet Trust, Tasha Scholarship en_US
dc.language.iso en en_US
dc.subject laparoscopy en_US
dc.subject pneumoperitoneum en_US
dc.subject ovariectomy en_US
dc.subject rabbit en_US
dc.subject Oryctolagus cuniculus en_US
dc.title Carbon Dioxide Pneumoperitoneum and Laparoscopic Ovariectomy in the Domestic Rabbit (Oryctolagus cuniculus) en_US
dc.type Thesis en_US
dc.degree.programme Clinical Studies en_US
dc.degree.name Doctor of Veterinary Science en_US
dc.degree.department Department of Clinical Studies en_US
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.


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