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Investigating the tonsillar viral profile of nursery pigs in farms with outbreaks of Streptococcus suis

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dc.contributor.advisor Poljak, Zvonimir
dc.contributor.author Kuruppu, Kaushalya
dc.date.accessioned 2019-09-04T17:00:19Z
dc.date.available 2019-09-04T17:00:19Z
dc.date.copyright 2019-08
dc.date.created 2019-08-23
dc.date.issued 2019-09-04
dc.identifier.uri http://hdl.handle.net/10214/17369
dc.description.abstract Streptococcus suis disease is complex and little is known about viral factors and their impact on clinical outcome. In the first study, a subset of 25 cases and 27 controls were screened for the presence of influenza A virus (IAV), porcine circovirus 2 (PCV-2), porcine respiratory and reproductive syndrome virus (PRRSV), porcine parvovirus (PPV), hemagglutinin encephalomyelitis virus (PHEV) and swine cytomegalovirus (SCMV) in their tonsils using polymerase chain reaction. A majority of S. suis cases and healthy controls were SCMV-positive pigs, including 52% of all cases and 67% of controls. In the second study, we investigated the association between tonsillar viral metagenome and S. suis disease in 27 clinically affected nursery pigs and 29 healthy, age-matched controls. We identified the importance and functional relationship of viral families such as Podoviridae, Smacoviridae, Astroviridae as well as species richness for improving the predictability of S. suis clinical disease. en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.subject swine en_US
dc.subject streptococcus suis en_US
dc.subject virus en_US
dc.subject next generation sequencing en_US
dc.subject nursery pigs en_US
dc.subject virome en_US
dc.title Investigating the tonsillar viral profile of nursery pigs in farms with outbreaks of Streptococcus suis en_US
dc.type Thesis en_US
dc.degree.programme Population Medicine en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Population Medicine en_US
dc.description.embargo 2020-08-23
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.degree.grantor University of Guelph en_US


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