Title:
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Opiate Withdrawal and Conditioned Withdrawal Enhance Consolidation of Object Memory in Male Sprague-Dawley Rats |
Author:
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Baidoo, Nana
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Department:
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Department of Psychology |
Program:
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Neuroscience |
Advisor:
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Leri, Francesco |
Abstract:
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The present study explored the effects of acute precipitated and conditioned withdrawal on object memory. Using the object recognition task, it was first demonstrated that 3 mg/kg naltrexone enhanced memory in morphine-maintained (osmotic mini-pumps;10 mg/kg/day) rats when administered immediately but not 6 h post-sample. Importantly, post-sample naltrexone enhanced memory in the same animals 7 days later following removal of mini pumps. To establish that conditioned withdrawal could also alter memory, morphine-maintained animals received naltrexone in a distinctive context (CS+) and vehicle in a separate context (CS-) alternatively over 10 days. At the end of conditioning, confinement to this CS+ produced a conditioned locomotion suppression. More important, immediate but not delayed post-sample exposure to CS+ enhanced memory. These experiments indicate that both acute precipitated and conditioned withdrawal have significant facilitatory effects on memory consolidation and thus can play a role in the development of addictive behaviours. |
URI:
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http://hdl.handle.net/10214/17359
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Date:
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2019-08 |
Rights:
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Attribution-NonCommercial-NoDerivatives 4.0 International |
Terms of Use:
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