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The effects of BPA and BPS on microRNAs during bovine oocyte maturation and early embryo development

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Title: The effects of BPA and BPS on microRNAs during bovine oocyte maturation and early embryo development
Author: Sabry, Reem
Department: Department of Biomedical Sciences
Program: Biomedical Sciences
Advisor: LaMarre, JonathanFavetta, Laura
Abstract: This thesis investigates the effects of endocrine disrupting chemicals, Bisphenol A and Bisphenol S, on the expression of microRNAs during bovine oocyte maturation and early embryo development. Regulation of development involves crucial events that are uniquely susceptible to EDC interference that can inappropriately activate cellular pathways. While the resulting effects on fertility are probably the result of changes in canonical gene expression, evidence is emerging to suggest that small noncoding RNAs known as microRNAs may also be participants in the response to EDCs. This study hypothesized that EDCs alter expression of key miRNAs during development. To this end, miR-21, -155, -34c, -146a expression were examined in an in vitro bovine model of matured cumulus-oocyte complexes, fertilized embryos, and cultured cumulus cells treated with BPA or BPS. The experimental data reveals alterations in microRNA expression after BPA treatment but not in BPS treatment, suggesting that it may act differently than BPA.
URI: http://hdl.handle.net/10214/16975
Date: 2019-08
Rights: Attribution 4.0 International
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Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International