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ANGPTL4 and omega-3 polyunsaturated fatty acids as mediators of lipid homeostasis in different metabolic states

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Title: ANGPTL4 and omega-3 polyunsaturated fatty acids as mediators of lipid homeostasis in different metabolic states
Author: Rajna, Alexander
Department: Department of Human Health and Nutritional Sciences
Program: Human Health and Nutritional Sciences
Advisor: Mutch, David
Abstract: This thesis investigated the relationship between omega-3 polyunsaturated fatty acids (n-3 PUFA), white adipose tissue (WAT) angiopoietin-like 4 (ANGPTL4) expression, and metabolic state-dependent lipid homeostasis. C57BL/6J mice fed low-fat diets containing n-3 PUFA had reduced plasma NEFA and liver TAG accumulation in the fasted state, while in WAT, markers of lipogenesis were reduced, and markers of lipolysis were increased. Additionally, n-3 PUFA increased WAT Angptl4 gene expression. In contrast, n-3 PUFA reduced plasma TAG in the fed state but had no effect on Angptl4 gene expression. Collectively, this thesis suggests that n-3 PUFA regulate lipid metabolism in a metabolic-state dependent manner, and that these important fatty acids may work via differential regulation of Angptl4 in WAT.
URI: http://hdl.handle.net/10214/16974
Date: 2019-08
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