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Conditioned aversive responses produced by delayed, but not immediate, exposure to cocaine in male Sprague-Dawley rats

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dc.contributor.advisor Parker, Linda
dc.contributor.author Guenther, Kelsey
dc.date.accessioned 2019-07-31T14:45:27Z
dc.date.available 2019-07-31T14:45:27Z
dc.date.copyright 2019-07-30
dc.date.created 2019-07-24
dc.date.issued 2019-07-31
dc.identifier.uri http://hdl.handle.net/10214/16717
dc.description.abstract Cocaine abuse is accompanied by the emergence of negative affect such as dysphoria irritability and anhedonia. Cues associated with cocaine are rapidly learned by animals and are capable of eliciting a negative affective state that can trigger relapse, indicating a critical role for associative mechanisms in the regulation of drug seeking. Using the taste reactivity test, the conditions under which a taste paired with delayed cocaine is able to elicit a conditionally aversive state was examined. It is demonstrated that delayed cocaine produces conditioned gaping when saccharin is paired with either a 10- or 30-min delay, whereas immediate cocaine does not result in aversive behaviours. Morphine also produces conditioned gaping in the 10 min procedure. Rats who received delayed cocaine-paired saccharin exhibit increased anxiety-like behaviours. Saccharin needed to be administered intermittently throughout the delay in order to produce the conditioned aversive state. Pre-treatment with ondansetron, SCH 23390 or OlGly interfered with the establishment of conditioned gaping to saccharin paired with delayed cocaine, but only during early trials. en_US
dc.language.iso en en_US
dc.subject Cocaine en_US
dc.subject Negative affect en_US
dc.subject Withdrawal en_US
dc.subject Taste reactivity en_US
dc.subject Aversion en_US
dc.subject Morphine en_US
dc.subject LiCl en_US
dc.subject Rat en_US
dc.title Conditioned aversive responses produced by delayed, but not immediate, exposure to cocaine in male Sprague-Dawley rats en_US
dc.degree.programme Psychology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Psychology en_US
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