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Conditioned aversive responses produced by delayed, but not immediate, exposure to cocaine in male Sprague-Dawley rats

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Title: Conditioned aversive responses produced by delayed, but not immediate, exposure to cocaine in male Sprague-Dawley rats
Author: Guenther, Kelsey
Department: Department of Psychology
Program: Psychology
Advisor: Parker, Linda
Abstract: Cocaine abuse is accompanied by the emergence of negative affect such as dysphoria irritability and anhedonia. Cues associated with cocaine are rapidly learned by animals and are capable of eliciting a negative affective state that can trigger relapse, indicating a critical role for associative mechanisms in the regulation of drug seeking. Using the taste reactivity test, the conditions under which a taste paired with delayed cocaine is able to elicit a conditionally aversive state was examined. It is demonstrated that delayed cocaine produces conditioned gaping when saccharin is paired with either a 10- or 30-min delay, whereas immediate cocaine does not result in aversive behaviours. Morphine also produces conditioned gaping in the 10 min procedure. Rats who received delayed cocaine-paired saccharin exhibit increased anxiety-like behaviours. Saccharin needed to be administered intermittently throughout the delay in order to produce the conditioned aversive state. Pre-treatment with ondansetron, SCH 23390 or OlGly interfered with the establishment of conditioned gaping to saccharin paired with delayed cocaine, but only during early trials.
URI: http://hdl.handle.net/10214/16717
Date: 2019-07-30
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