Title:
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Conditioned aversive responses produced by delayed, but not immediate, exposure to cocaine in male Sprague-Dawley rats |
Author:
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Guenther, Kelsey
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Department:
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Department of Psychology |
Program:
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Psychology |
Advisor:
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Parker, Linda |
Abstract:
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Cocaine abuse is accompanied by the emergence of negative affect such as dysphoria irritability and anhedonia. Cues associated with cocaine are rapidly learned by animals and are capable of eliciting a negative affective state that can trigger relapse, indicating a critical role for associative mechanisms in the regulation of drug seeking. Using the taste reactivity test, the conditions under which a taste paired with delayed cocaine is able to elicit a conditionally aversive state was examined. It is demonstrated that delayed cocaine produces conditioned gaping when saccharin is paired with either a 10- or 30-min delay, whereas immediate cocaine does not result in aversive behaviours. Morphine also produces conditioned gaping in the 10 min procedure. Rats who received delayed cocaine-paired saccharin exhibit increased anxiety-like behaviours. Saccharin needed to be administered intermittently throughout the delay in order to produce the conditioned aversive state. Pre-treatment with ondansetron, SCH 23390 or OlGly interfered with the establishment of conditioned gaping to saccharin paired with delayed cocaine, but only during early trials. |
URI:
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http://hdl.handle.net/10214/16717
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Date:
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2019-07-30 |
Terms of Use:
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