Main content

Effects of Early, Elevated Prenatal Testosterone on the HPA Axis and Hormone Responsiveness in Mice

Show simple item record

dc.contributor.advisor MacLusky, Neil James
dc.contributor.advisor Choleris, Elena Wilson, Hayley Ann 2019-05-15T20:35:00Z 2019-05-15T20:35:00Z 2019-05 2019-05-07 2019-05-15
dc.description.abstract Alterations in developmental testosterone exposure can affect social and anxiety behaviour in male offspring, however, the underlying mechanisms remain unknown. We hypothesized that prenatal testosterone exposure would impact physiological development in a similar way as prenatal glucocorticoid exposure, resulting in altered hypothalamic-pituitary-adrenal axis functioning and hormone profiles in offspring. We treated dams with testosterone propionate, the synthetic glucocorticoid dexamethasone, or sesame oil during mid-late pregnancy. Testosterone was measured in male offspring on the day of birth and in adulthood. Corticosterone was measured in offspring’s hair, and in plasma following restraint stress. Prenatal treatment did not affect offspring testosterone levels. While prenatal testosterone had no effect on corticosterone levels in hair, prenatal testosterone reduced corticosterone responsivity to restraint stress in males, but not females. No effects of prenatal dexamethasone on corticosterone responsivity was observed. This study may have potential implications for conditions in which testosterone or dexamethasone are elevated during pregnancy. en_US
dc.description.sponsorship Natural Sciences and Engineering Research Council of Canada en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International *
dc.rights.uri *
dc.subject testosterone en_US
dc.subject sex differences en_US
dc.subject HPA axis en_US
dc.subject prenatal development en_US
dc.title Effects of Early, Elevated Prenatal Testosterone on the HPA Axis and Hormone Responsiveness in Mice en_US
dc.type Thesis en_US Biomedical Sciences en_US Master of Science en_US Department of Biomedical Sciences en_US University of Guelph en_US

Files in this item

Files Size Format View
Wilson_Hayley_201904_MSc.pdf 1.871Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
The library is committed to ensuring that members of our user community with disabilities have equal access to our services and resources and that their dignity and independence is always respected. If you encounter a barrier and/or need an alternate format, please fill out our Library Print and Multimedia Alternate-Format Request Form. Contact us if you’d like to provide feedback:  (email address)