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In vitro and in ovo characterization of aquatic bird bornavirus 1 in avian species

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dc.contributor.advisor Susta, Leonardo
dc.contributor.author Leacy, Alexander
dc.date.accessioned 2019-05-15T20:16:43Z
dc.date.available 2019-05-15T20:16:43Z
dc.date.copyright 2019-05
dc.date.created 2019-05-09
dc.date.issued 2019-05-15
dc.identifier.uri http://hdl.handle.net/10214/16110
dc.description.abstract Aquatic bird bornavirus 1 (ABBV-1) is associated with fatal inflammation of nervous tissue in avian species. Waterfowl act as the natural host, with populations of Canada geese existing as carriers in North America, however ABBV-1 has been detected from other non-waterfowl species. The objective of this thesis was to characterize the host range of ABBV-1 to determine the relative threat to the poultry industry. Studies were conducted to: 1) characterize ABBV-1 in continuous avian cell lines, 2) assess ABBV-1 replication kinetics in primary goose, duck, chicken and turkey fibroblasts, and 3) evaluate an in ovo model to assess ABBV-1 host restriction and pathogenesis. The results indicated that poultry species were semi-permissive to infection in vitro at decreased rates compared to natural hosts. Inoculation in ovo was ineffective in inducing virus spread and lesions in any species, making it unsuitable to study ABBV-1. This work will inform future research regarding ABBV-1. en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject aquatic bird bornavirus 1 en_US
dc.subject avian bornavirus en_US
dc.subject Bornaviridae en_US
dc.subject waterfowl en_US
dc.subject poultry en_US
dc.subject cell lines en_US
dc.subject host range en_US
dc.subject growth curves en_US
dc.subject in ovo pathogenesis en_US
dc.subject experimental infection en_US
dc.title In vitro and in ovo characterization of aquatic bird bornavirus 1 in avian species en_US
dc.type Thesis en_US
dc.degree.programme Pathobiology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Pathobiology en_US
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