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Investigating the Association Between Genetic Variants and Response to a One-Year Lifestyle Intervention Targeting Metabolic Syndrome

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dc.contributor.advisor Mutch, David
dc.contributor.author Lowry, Dana
dc.date.accessioned 2019-05-09T19:15:13Z
dc.date.available 2019-05-09T19:15:13Z
dc.date.copyright 2019-05
dc.date.created 2019-04-30
dc.date.issued 2019-05-09
dc.identifier.uri http://hdl.handle.net/10214/16028
dc.description.abstract Although lifestyle interventions are generally successful for reducing metabolic syndrome (MetS) risk, significant variability in response between people exists. This thesis investigated factors that influence response to a 1-year, personalized, team-based lifestyle intervention targeting individuals with MetS. Using data collected from the Canadian Health Advanced by Nutrition and Graded Exercise (CHANGE) program, it was found that reductions in continuous MetS (cMetS) score at 3 months and 1 year were associated with two single nucleotide polymorphisms: rs662799 (A/G) in apolipoprotein A5 (APOA5) and rs1501299 (G/T) in adiponectin (ADIPOQ). Next, predictive models were developed to investigate if baseline variables could predict cMetS score at 1 year in the CHANGE program. Baseline systolic blood pressure and short-term changes in cMetS score were found to be predictive of 1-year cMetS score. Collectively, this thesis demonstrates the power of genetic and bioclinical measurements to unravel the inter-individual variability in response to lifestyle interventions targeting MetS. en_US
dc.language.iso en en_US
dc.title Investigating the Association Between Genetic Variants and Response to a One-Year Lifestyle Intervention Targeting Metabolic Syndrome en_US
dc.type Thesis en_US
dc.degree.programme Human Health and Nutritional Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Human Health and Nutritional Sciences en_US
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