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Intraarticular xenogeneic mesenchymal stem cell-based therapy increases CD4+CD25+ cells in the synovial fluid but does not contribute to pathological change

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Title: Intraarticular xenogeneic mesenchymal stem cell-based therapy increases CD4+CD25+ cells in the synovial fluid but does not contribute to pathological change
Author: Lamers, Kristen
Department: Department of Clinical Studies
Program: Clinical Studies
Advisor: Hurtig, Mark
Abstract: Mesenchymal stem cells have been investigated for their potential use in OA treatment. Experimental xenogeneic mesenchymal stem cell-based therapy treatment of a normal and OA ovine knee (stifle) induced CD4+ cell infiltration and increased CD25 activation marker expression on the CD4+ cells. This cell infiltration was not associated with pathologic change, indicating that these were not likely to be Th1 or Th17 cells, both of which are increased in OA synovial membrane. Cell therapy may promote Th2 and/or Treg cell differentiation and thereby increases expression of anti-inflammatory cytokines. Xenogeneic cell therapy was not associated with a graft versus host reaction.
URI: http://hdl.handle.net/10214/16022
Date: 2019-05
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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Attribution-NonCommercial-NoDerivatives 4.0 International Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International