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Investigating Dlx and Zbed1 Protein Interactions During Cell Cycle Progression

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Title: Investigating Dlx and Zbed1 Protein Interactions During Cell Cycle Progression
Author: McLaughlin, Michael Shayne
Department: Department of Molecular and Cellular Biology
Program: Molecular and Cellular Biology
Advisor: Bendall, Andrew
Abstract: Genes of the vertebrate distal-less homeobox (Dlx) family encode a group of homeodomain transcription factors that act as pro-differentiation factors in a variety of tissues. Recently, we have shown that forced expression of both Dlx5 and Dlx6 decreases the rate of cellular proliferation in various cell types, at least in part by delaying entry into S-phase. In Drosophila, this may be accomplished by a protein-protein interaction involving the homologue Distal-less (Dll) and the DNA replication-related element binding factor (DREF) – a pro-proliferative transcription factor that positively regulates many genes associated with cell cycle progression. Here, we demonstrate that this interaction may be a conserved mechanism for Dlx-mediated antagonism of cell division since chick Dlx6 physically interacts with the chick orthologue of DREF, Zbed1. We investigated the functional significance of this physical interaction by examining aspects of cell cycle progression in several cell lines.
Date: 2019-03-28
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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Attribution-NonCommercial-NoDerivatives 4.0 International Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International