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Salmonella antibody response on commercial swine farms and its association with host genetics and isolation of Salmonella on-farm and at slaughter

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Title: Salmonella antibody response on commercial swine farms and its association with host genetics and isolation of Salmonella on-farm and at slaughter
Author: Schut, Corinne
Department: Department of Pathobiology
Program: Pathobiology
Advisor: Lillie, BrandonFarzan, Vahab
Abstract: Salmonella in pork is a concern. This study characterized pig antibody responses on-farm and their association with Salmonella shedding/tissue colonization and host genetic variants. Fourteen cohorts of pigs from eight farms (total = 809) were tested five times (weaning to slaughter). Blood and feces/tissues were analyzed via ELISA and culturing. Data were analyzed using mixed-effects logistic regression models. Overall, 20.7% of sera tested positive for Salmonella antibodies and 12.6% of fecal samples tested positive for Salmonella. Older pigs and pigs shedding Salmonella were more likely to test seropositive (p < 0.05). There was no association between seropositivity and Salmonella at slaughter. Variants in/near PTPRJ (p = 0.0000066), ST6GALNAC3 (p = 0.0000099), and DCDC2C (p < 0.0000086) were associated with Salmonella susceptibility, while variants in AKAP12 (p < 0.0000358) and RALGAPA2 (p = 0.0000760) may be associated. This work may aid research in reducing Salmonella on-farm, benefiting researchers and the public.
URI: http://hdl.handle.net/10214/14776
Date: 2019-01
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