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Pre-clinical and Clinical Assessment of pathological change in Osteoarthritis using Contrast-Enhanced micro-Computed Tomography and real-time Analysis of Serial CT in sheep.

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Title: Pre-clinical and Clinical Assessment of pathological change in Osteoarthritis using Contrast-Enhanced micro-Computed Tomography and real-time Analysis of Serial CT in sheep.
Author: Flynn, Candace
Department: Department of Clinical Studies
Program: Clinical Studies
Advisor: Hurtig, Mark
Abstract: Osteoarthritis is a prominent disease that can affect any joint in the body, and has been commonly observed in both human and veterinary medicine. Use of semi-quantitative scoring techniques for the clinical assessment of the disease has lately been scrutinized for their exclusion of imaging biomarkers indicative of early stages of the disease. This thesis presents two quantitative approaches using computed tomography (CT) for pre-clinical and clinical assessment of OA. Degenerative changes in the physical and biochemical structure of cartilage have been captured using contrast-enhanced micro-computed tomography (CE-μCT). The first study examines the utility of CE-μCT in reflecting local differences in sulfated-glycosaminoglycan (sGAG) and how biochemical integrity may differ between early and late stages of OA. The second study demonstrates real-time analysis of OA progression by analyzing changes in the rate of bone growth in live sheep developing OA after meniscal destabilization. These thesis provides insight to two quantitative approaches to assessing OA severity using CT that could be easily implemented in laboratory and clinical settings.
URI: http://hdl.handle.net/10214/14758
Date: 2018-12


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