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Effect of Tracheal Antimicrobial Peptide on the Development of Mannheimia haemolytica Pneumonia in Cattle

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Title: Effect of Tracheal Antimicrobial Peptide on the Development of Mannheimia haemolytica Pneumonia in Cattle
Author: Vulikh, Ksenia
Department: Department of Pathobiology
Program: Pathobiology
Advisor: Caswell, Jeff
Abstract: Respiratory disease causes significant economic loss to the beef industry. Tracheal antimicrobial peptide (TAP) is naturally produced in bovine airways and has bactericidal activity against the pathogens that cause pneumonia in cattle, but its expression is suppressed by glucocorticoid (stress) and viral infection. We hypothesized that, in calves challenged with Mannheimia haemolytica, administering TAP to the respiratory tract would prevent pneumonia. In a novel Mannheimia challenge model using partially colostrum-deprived calves, treatment with non-oxidized TAP did not reduce bacterial loads in the respiratory tract or protect against disease. Sodium chloride and serum inhibited bactericidal activity of TAP. These findings suggest that TAP does not control bacterial infections in vivo because of interference by physiological salt levels and serum in inflamed tissues. Thus, stimulation of TAP expression in calves at risk of disease may not be effective for disease prevention in vivo.
URI: http://hdl.handle.net/10214/14725
Date: 2018-12
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