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The effect of aging on single muscle fibre and whole muscle contractile properties

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dc.contributor.advisor Power, Geoffrey
dc.contributor.advisor Brown, Stephen
dc.contributor.author Mazara, Nicole
dc.date.accessioned 2019-01-02T15:12:50Z
dc.date.available 2019-12-10T06:00:36Z
dc.date.copyright 2018-12
dc.date.created 2018-12-10
dc.date.issued 2019-01-02
dc.identifier.uri http://hdl.handle.net/10214/14693
dc.description.abstract The aims of this thesis were to determine if whole muscle rate of torque development (RTD) and single fibre rate of force redevelopment (ktr) are lower in older adults compared to young adults, if ktr and RTD are associated with each other, and if ktr is affected by [Ca2+] in humans. Knee extensor muscle strength, speed, power, and RTD were lower in old compared to young. Single fibre ktr was not different between young and old. There were ktr-RTD relationships trending toward significance in older TI fibres. Human single fibre ktr was also affected by [Ca2+] such that with increasing [Ca2+] ktr increased. In old single fibres, calcium sensitivity (pCa50) was strongly associated with ktr, such that with increasing pCa50, ktr increased. This work has confirmed the ktr-[Ca2+] relationship in humans and found an emerging relationship between ktr and RTD in older adults. en_US
dc.language.iso en en_US
dc.subject Muscle en_US
dc.subject Aging en_US
dc.subject Single Fibre en_US
dc.subject Cellular mechanics en_US
dc.subject Contractile properties en_US
dc.subject Rate of force redevelopment en_US
dc.subject Rate of torque development en_US
dc.title The effect of aging on single muscle fibre and whole muscle contractile properties en_US
dc.type Thesis en_US
dc.degree.programme Human Health and Nutritional Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Human Health and Nutritional Sciences en_US
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