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The RNA-binding Protein hnRNP Q Regulates Dendritic Morphogenesis and Synapse Number in Cortical Neurons

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dc.contributor.advisor Vessey, John
dc.contributor.author Thorpe, Hayley
dc.date.accessioned 2018-12-11T13:58:05Z
dc.date.copyright 2018-11
dc.date.created 2018-11-19
dc.date.issued 2018-12-11
dc.identifier.uri http://hdl.handle.net/10214/14592
dc.description.abstract Heterogeneous nuclear ribonucleoproteins (hnRNP) constitute a family of RNA-binding proteins (RBP) capable of regulating mRNA dynamics and protein translation. Mutations in one such protein, hnRNP Q, were recently identified as a potential cause of human intellectual disorders. This protein is highly expressed in the neocortex during peak neurogenic periods and is suggested to be a mediator of neurogenesis and facets of interneuronal connectivity, including dendritogenesis and synaptogenesis. This research aimed to identify a role for hnRNP Q in the maturation of newborn cortical neurons by knocking down hnRNP Q in vitro and analyzing dendritic complexity and synaptic density. Dendritic complexity as evaluated by Sholl analysis was increased in hnRNP Q-depleted neurons and these neurons also demonstrated lower synapse density relative to control neurons. This suggests that hnRNP Q is critical to neuron development and morphogenesis, and aberrant hnRNP Q expression could result in intellectual disorders in humans. en_US
dc.language.iso en en_US
dc.subject Neurodevelopment en_US
dc.subject RNA-binding proteins en_US
dc.subject Cellular morphogenesis en_US
dc.subject Synaptogenesis en_US
dc.title The RNA-binding Protein hnRNP Q Regulates Dendritic Morphogenesis and Synapse Number in Cortical Neurons en_US
dc.type Thesis en_US
dc.degree.programme Molecular and Cellular Biology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Molecular and Cellular Biology en_US
dc.description.embargo 2019-11-19
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