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Role of Hippo Signaling Pathway During Bovine Oocyte Maturation In-Vitro

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dc.contributor.advisor Madan, Pavneesh Carvajal, Diana 2018-12-07T18:42:39Z 2018-12-07T18:42:39Z 2018-12 2018-12-03 2018-12-07
dc.description.abstract Oocyte development is strictly regulated by several ovarian signaling pathways. One of these pathways is the Hippo signaling pathway, known for its role in cell proliferation and apoptosis. Limited but substantial evidence has demonstrated that the Hippo signaling pathway plays a significant role in ovarian function. However, its involvement during specific stages of oocyte development remains elusive. This is the first report characterizing the expression and protein localization of Hippo pathway components during bovine oocyte maturation. Results provide new knowledge that the Hippo signaling pathway is involved during oocyte maturation in bovine species, and that the expression and localization of the components depend greatly on the presence or absence of cumulus cells and on specific stages of development. Results also provide insight about the role of cumulus cells in modulating pathway components and the importance of these components during oocyte maturation, which contribute to the development of competent oocytes. en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.subject Hippo signaling pathway en_US
dc.subject MST1/2 en_US
dc.subject LATS1/2 en_US
dc.subject YAP en_US
dc.subject TAZ en_US
dc.subject Oocyte maturation en_US
dc.subject Bovine en_US
dc.title Role of Hippo Signaling Pathway During Bovine Oocyte Maturation In-Vitro en_US
dc.type Thesis en_US Biomedical Sciences en_US Master of Science en_US Department of Biomedical Sciences en_US
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated. University of Guelph en_US

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