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A dynamic model for assessing universal Hepatitis A vaccination in Canada

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dc.contributor.author Bauch, C.T.
dc.contributor.author Rao, Arni S.R. Srinivasa
dc.contributor.author Pham, B.Z.
dc.contributor.author Krahn, M.
dc.contributor.author Gilca, V.
dc.contributor.author Duval, B.
dc.contributor.author Chen, M.H.
dc.contributor.author Tricco, A.C.
dc.date.accessioned 2018-09-24T14:05:12Z
dc.date.available 2018-09-24T14:05:12Z
dc.date.copyright 2006
dc.date.issued 2006-09-05
dc.identifier.uri http://hdl.handle.net/10214/14319
dc.description.abstract Vaccination against Hepatitis A virus (HAV) in Canada is currently targeted toward high-risk groups. However, universal vaccination has been adopted in several other countries with a similar disease burden. Here we develop an age-structured compartmental model of HAV transmission and vaccination in Canada to assess potential universal vaccination strategies. The model predicts that universal vaccination at age 1 (respectively 4, 9, 15), with phasing out of targeted vaccination, would reduce reported incidence by 60% (respectively 52%, 36%, 31%) and mortality attributable to HAV by 56% (respectively 45%, 26%, 25%), relative to continued targeted vaccination, over eighty years.
dc.language.iso en
dc.publisher Elsevier
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Hepatitis A
dc.subject transmission model
dc.subject universal vaccination
dc.title A dynamic model for assessing universal Hepatitis A vaccination in Canada
dc.type Article
dc.rights.holder Copyright 2007 Elsevier Ltd. All rights reserved.
dcterms.relation Bauch, C.T., Rao, Arni S.R. Srinivasa, Pham, B.Z., Krahn, M., Gilca, V., Duval, B., Chen, M.H., and Tricco, A.C. (2007). A dynamic model for assessing universal Hepatitis A vaccination in Canada. Vaccine. 25(10): 1719-1726. https://doi.org/10.1016/j.vaccine.2006.11.020


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