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A dynamic model for assessing universal Hepatitis A vaccination in Canada

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Title: A dynamic model for assessing universal Hepatitis A vaccination in Canada
Author: Bauch, C.T.; Rao, Arni S.R. Srinivasa; Pham, B.Z.; Krahn, M.; Gilca, V.; Duval, B.; Chen, M.H.; Tricco, A.C.
Abstract: Vaccination against Hepatitis A virus (HAV) in Canada is currently targeted toward high-risk groups. However, universal vaccination has been adopted in several other countries with a similar disease burden. Here we develop an age-structured compartmental model of HAV transmission and vaccination in Canada to assess potential universal vaccination strategies. The model predicts that universal vaccination at age 1 (respectively 4, 9, 15), with phasing out of targeted vaccination, would reduce reported incidence by 60% (respectively 52%, 36%, 31%) and mortality attributable to HAV by 56% (respectively 45%, 26%, 25%), relative to continued targeted vaccination, over eighty years.
Date: 2006
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Rights Holder: Copyright 2007 Elsevier Ltd. All rights reserved.

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Attribution-NonCommercial-NoDerivatives 4.0 International Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International