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Cervical screening adherence in the era of HPV vaccination: how low is too low?

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dc.contributor.author Bauch, Chris T.
dc.contributor.author Li, Meng
dc.contributor.author Chapman, Gretchen
dc.contributor.author Galvani, Alison P.
dc.date.accessioned 2018-09-24T14:05:11Z
dc.date.available 2018-09-24T14:05:11Z
dc.date.copyright 2009
dc.date.issued 2009-09-21
dc.identifier.citation Bauch, C. T., Li, M., Chapman, G., and Galvani, A. P. (2010). Adherence to cervical screening in the era of human papillomavirus vaccination: how low is too low?. The Lancet Infectious Diseases. 10(2): 133-137. https://doi.org/10.1016/S1473-3099(10)70004-9
dc.identifier.uri http://hdl.handle.net/10214/14317
dc.description.abstract The recently licensed human papillomavirus (HPV) vaccine prevents infection by two major oncogenic HPV types. However, continued screening in vaccinated women is necessary to prevent cancers caused by high-risk types not included in the vaccine. In the vaccine era, there is new concern that vaccinated women will reduce their rate of screening due to an exaggerated sense of protection from the vaccine. Some have suggested this could paradoxically lead to an increase in the incidence of cervical cancer. Here, we present a simple mathematical model suggesting that this outcome is unlikely. This result applies under a wide range of possible vaccine coverage levels and screening programme effectiveness. In populations that currently have highly effective cervical screening programmes, screening rates in vaccinated women have less room to fall before cervical cancer incidence starts to increase in the vaccine era, although the required declines are still very steep.
dc.language.iso en
dc.publisher Elsevier
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject HPV
dc.subject screening
dc.subject vaccination
dc.subject cervical cancer
dc.subject cervical screening programmes
dc.title Cervical screening adherence in the era of HPV vaccination: how low is too low?
dc.type Article
dc.rights.holder Copyright 2010 Elsevier B.V. All rights reserved.
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.


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