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The Long-Term Effects of Environmental Enrichment on Agonism in Female C57BL/6, DBA/2, and BALB/c Mice

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dc.contributor.advisor Mason, Georgia Nip, Emma 2018-09-13T15:42:12Z 2018-09-13T15:42:12Z 2018-09 2018-09-06 2018-09-13
dc.description.abstract Female mice are usually kept in non-enriched shoebox cages that increase agonism. I sought to understand why environmental enrichment (EE) reduces agonism by observing home-cage agonism, stereotypic behaviour, and inactive-but-awake behaviour (IBA: a depressive-like state), and by assessing hearing loss and anxiety, in 165 mice (C57BL/6s, BALB/cs, and DBA/2s). I employed statistics to see if any of these variables predicted agonism; only IBA did in some sub-groups. Low agonism in EE mice was also partially explained by low social interaction rates. Lastly, I assessed agonism in an unfamiliar arena with stranger mice, but enriched mice did not exhibit less agonism in this setting. Overall, these findings demonstrate that a) EE reduces agonism in females, b) IBA co-varies with agonism, c) low agonism is partially a by-product of low interaction rates, and d) enriched mice are no less agonistic than non-enriched mice when in an unfamiliar arena with strangers. en_US
dc.description.sponsorship GEES and OGS scholarships en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.subject Enrichment en_US
dc.subject Environmental Enrichment en_US
dc.subject Mice en_US
dc.subject Female en_US
dc.subject Aggression en_US
dc.subject Agonism en_US
dc.subject DBA/2 en_US
dc.subject C57BL/6 en_US
dc.subject BALB/c en_US
dc.title The Long-Term Effects of Environmental Enrichment on Agonism in Female C57BL/6, DBA/2, and BALB/c Mice en_US
dc.type Thesis en_US Animal and Poultry Science en_US Master of Science en_US Department of Animal Biosciences en_US
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated. University of Guelph en_US

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