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The effect of an immune stimulant on the incidence of clinical disease, production, and reproduction in early lactation dairy cows

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dc.contributor.advisor LeBlanc, Stephen
dc.contributor.author Van Schyndel, Sabrina
dc.date.accessioned 2018-09-10T13:58:40Z
dc.date.copyright 2018-08
dc.date.created 2018-08-30
dc.date.issued 2018-09-10
dc.identifier.uri http://hdl.handle.net/10214/14272
dc.description.abstract Impaired immune function causes reproductive disease in many high-producing dairy cattle during the periparturient period, primarily due to a reduction in the number and function of neutrophils. When administered to periparturient dairy cattle, pegbovigrastim has been shown to dramatically increase circulating neutrophil counts, by stimulating their production and release from bone marrow. The objective of the research described in this thesis was to examine the effects of pegbovigrastim treatment on reproductive performance, and clinical disease and milk production in early lactation. The primary study was a large-scale, double-blind, randomized controlled trial, involving 1,607 cows in 6 commercial herds. Pegbovigrastim had no effect on retained placenta (RP), displaced abomasum, clinical mastitis, endometritis, or reproductive performance outcomes. However, cows with RP were less likely to develop metritis, heifers were more likely to have purulent vaginal discharge, and milk production was reduced in cows treated with pegbovigrastim, compared to controls. en_US
dc.description.sponsorship Elanco Canada Ltd. en_US
dc.language.iso en en_US
dc.subject dairy cows en_US
dc.subject cattle en_US
dc.subject immune stimulant en_US
dc.subject pegbovigrastim en_US
dc.title The effect of an immune stimulant on the incidence of clinical disease, production, and reproduction in early lactation dairy cows en_US
dc.type Thesis en_US
dc.degree.programme Population Medicine en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Population Medicine en_US
dc.description.embargo 2019-07-31


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