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The effects of monounsaturated and n-3 polyunsaturated fatty acids on resting blood pressure and muscle sympathetic nerve activity

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Title: The effects of monounsaturated and n-3 polyunsaturated fatty acids on resting blood pressure and muscle sympathetic nerve activity
Author: Lee, Jordan
Department: Department of Human Health and Nutritional Sciences
Program: Human Health and Nutritional Sciences
Advisor: Millar, Philip
Abstract: This thesis investigated whether the n-3 polyunsaturated fatty acids, EPA and DHA, as well as olive oil (OO), a source of monounsaturated fatty acids, exert differential effects on resting hemodynamics and muscle sympathetic outflow. Ninety young healthy men and women were randomized to 3g/day of either EPA (n=30), DHA (n=30), or OO (n=30) for 12 weeks. Continuous measurements of resting blood pressure and heart rate, and muscle sympathetic nerve activity (MSNA) in a subset of the participants, were recorded before and after supplementation. DHA and OO reduced systolic and diastolic blood pressure relative to EPA, whereas EPA increased heart rate. DHA increased MSNA compared to EPA and OO, whereas OO did not change MSNA relative to EPA. Although DHA and OO elicit hypotensive effects in healthy young individuals, DHA likely acts through peripheral vascular mechanisms resulting in baroreflex mediated compensatory sympathoexcitation, while OO could act through a central resetting mechanism.
URI: http://hdl.handle.net/10214/14188
Date: 2018-08
Rights: Attribution-NoDerivs 2.5 Canada
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Attribution-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NoDerivs 2.5 Canada