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Structural Influence of Hemicyanine Dyes in Optical Detection Platforms

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dc.contributor.advisor Manderville, Richard Chung, Andrew 2018-09-04T18:31:35Z 2018-12-01T06:00:13Z 2018-08-22 2018-08-22 2018-09-04
dc.description.abstract Hemicyanine dyes are highly conjugated fluorescent molecules that are composed of a D-π-A motif that exhibits the ability to push electrons from the donor towards the acceptor, generating emission and excitation wavelengths in the visible region. The research discussed in this thesis will demonstrate the utility of hemicyanine dyes for detection of thiolate anions and ochratoxin A. First, two hemicyanine dyes with commonly employed A moieties undergo nucleophilic addition with a simple thiolate to provide unambiguous 1H and 13C NMR evidence to distinguish the products of solvolysis from thiolate addition. For detection of OTA, various hemicyanine dyes are shown to bind to the ochratoxin A aptamer to produce a turn-on emission response. Addition of the toxin to the dye:aptamer complex resulted in loss of dye emission. For these studies, the nature of the A plays a critical role in the ability of OTA to displace the dye from the aptamer. en_US
dc.description.sponsorship NSERC, EBPI, Grain Farmers of Ontario, Government of Ontario en_US
dc.language.iso en en_US
dc.rights Attribution 2.5 Canada *
dc.rights.uri *
dc.subject Hemicyanine dyes en_US
dc.subject ochratoxin A en_US
dc.subject Thiolate sensing en_US
dc.subject Aptasensor technology en_US
dc.title Structural Influence of Hemicyanine Dyes in Optical Detection Platforms en_US
dc.type Thesis en_US Chemistry en_US Master of Science en_US Department of Chemistry en_US
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Attribution 2.5 Canada Except where otherwise noted, this item's license is described as Attribution 2.5 Canada