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Muscarinic Receptor Isoforms Differentially Regulate the Excitability of Medial Prefrontal Cortex Layer 6 Pyramidal Neurons in CD-1 mice

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dc.contributor.advisor Bailey, Craig
dc.contributor.author Patel, Ashutosh
dc.date.accessioned 2018-09-02T17:22:27Z
dc.date.available 2018-09-02T17:22:27Z
dc.date.copyright 2018-08
dc.date.created 2018-08-21
dc.date.issued 2018-09-02
dc.identifier.uri http://hdl.handle.net/10214/14161
dc.description.abstract Cholinergic signalling within the medial prefrontal cortex (mPFC) plays an important modulatory role in mPFC-dependent cognitive functions. This role is mediated by acetylcholine (ACh) activation of nicotinic (nAChR) and muscarinic (mAChR) receptors, which work together to regulate neuron function within the mPFC. Although pyramidal neurons in mPFC layer 6 express nAChRs that have been characterized thoroughly, they also express mAChRs that have not yet been investigated in detail. Using whole-cell electrophysiology in mouse brain sections, this thesis describes a physiological and pharmacological characterization of mAChR function in mPFC layer 6 neurons. ACh activation of mAChRs mediates a transient inhibitory response that is strongest in young postnatal life and mediated by M1, M2, and M3 isoforms, and a prolonged excitatory response that is not developmentally regulated and mediated primarily by M1 and M3 isoforms. To our knowledge, this work describes the first detailed characterization of mAChRs in mPFC layer 6. en_US
dc.language.iso en en_US
dc.rights Attribution-ShareAlike 2.5 Canada *
dc.rights.uri http://creativecommons.org/licenses/by-sa/2.5/ca/ *
dc.subject Muscarinic Receptors en_US
dc.subject Cholinergic Signalling en_US
dc.subject Acetylcholine en_US
dc.subject Electrophysiology en_US
dc.subject G Protein Coupled Receptors en_US
dc.subject Medial Prefrontal Cortex en_US
dc.title Muscarinic Receptor Isoforms Differentially Regulate the Excitability of Medial Prefrontal Cortex Layer 6 Pyramidal Neurons in CD-1 mice en_US
dc.type Thesis en_US
dc.degree.programme Neuroscience en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Biomedical Sciences en_US


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